When Isaac’s mother starts hearing the voice of God demanding a sacrifice be made to prove her faith, Isaac escapes into the basement facing droves of deranged enemies, lost brothers and sisters, his fears, and eventually his mother.

How long is The Binding of Isaac: Afterbirth+?
When focusing on the main objectives, The Binding of Isaac: Afterbirth+ is about 5 Hours in length. If you're a gamer that strives to see all aspects of the game, you are likely to spend around 354 Hours to obtain 100% completion.